This was the first pedal I bought when I was learning to play. I had a little Peavey 20 watt amp and the Boss pedal. It sounded like I was playing through a tin can, but I didn't know the difference back then.
My setup now has most of my distortion coming from a Marshall
half stack solid-state amp. I then run through a Boss ME-6 effects pedal (5 programmable pedals with 5 banks of storage) which I have pretty much stripped to nothing on the main setting. The other settings in the ME-6 have all my flanger, echo/delay, phase-shifting, and chorus settings. So through the ME-6 I get almost nothing for my main setting, so I'm still running my distortion off of the amp. Then I run to the Boss Distortion and have it set at about 6 for tone (1 O'clock) and about 7 (or 2:00-ish) for distortion. I have the level at about 4 (10 O'clock). Not turning up the level too high keeps me from getting the high end feedback. But the pedal really cleans up my tone so that the notes are more crisp and the low end isn't muddy at all. I tried using the pedal for the distortion with the clean channel of my amp, but it sounds too processed to me. I usually will leave it on with the settings I have now when I run through the clean channel of my amp and I get a nice bluesy tone. It's really a versatile little pedal for having limited controls. The sound is better than what the ME-6 gives me, and that cost about 3-4 times as much.