OK, I picked up the PODxt last nite and found that it sounds good through the Fender FM212R. Cheap amp ($289), but it sounds LOUD and actually the built in overdrive is quite nice. Still tweaking...
BTW, it sounded horrible through the Spider II. I do not think I was able to get a really DRY clean sound from it. The Fender gives me a nice punchy dry clean channel.